Revisiting the Temkin Isotherm: Dimensional Inconsistency and Approximate Forms

Revisiting inconsistency in large pharmacogenomic studies

In 2013, we published a comparative analysis of mutation and gene expression profiles and drug sensitivity measurements for 15 drugs characterized in the 471 cancer cell lines screened in the Genomics of Drug Sensitivity in Cancer (GDSC) and Cancer Cell Line Encyclopedia (CCLE). While we found good concordance in gene expression profiles, there was substantial inconsistency in the drug response...

existence and approximate $l^{p}$ and continuous solution of nonlinear integral equations of the hammerstein and volterra types

بسیاری از پدیده ها در جهان ما اساساً غیرخطی هستند، و توسط معادلات غیرخطی ‎‏بیان شد‎‎‏ه اند. از آنجا که ظهور کامپیوترهای رقمی با عملکرد بالا، حل مسایل خطی را آسان تر می کند. با این حال، به طور کلی به دست آوردن جوابهای دقیق از مسایل غیرخطی دشوار است. روش عددی، به طور کلی محاسبه پیچیده مسایل غیرخطی را اداره می کند. با این حال، دادن نقاط به یک منحنی و به دست آوردن منحنی کامل که اغلب پرهزینه و ...

Trade-offs, Transitivity, and Temkin †

The last few years have seen a number of new and important publications in moral theory. Arguably none more important than Larry S. Temkin’s Rethinking the Good: Moral Ideals and the Nature of Practical Reasoning. This fascinating work highlights and explores in depth a seemingly fundamental inconsistency in our own axiological beliefs. Put roughly, the inconsistency arises given our general wi...

Owsei Temkin 1902-2002.

Revisiting Reuse for Approximate Query Processing

Visual data exploration tools allow users to quickly gather insights from new datasets. As dataset sizes continue to increase, though, new techniques will be necessary to maintain the interactivity guarantees that these tools require. Approximate query processing (AQP) attempts to tackle this problem and allows systems to return query results at “human speed.” However, existing AQP techniques s...